THE BASIC PRINCIPLES OF SOK

The function of SIK1 in tumorigenesis. SIK1 can be a tumor suppressor gene, which performs a very important regulatory purpose in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and impacts most cancers cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may also adver